Complex relation ofHLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset

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Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset

OBJECTIVE To examine the relationship between 2 markers of early multiple sclerosis (MS) onset, 1 genetic (HLA-DRB1*1501) and 1 experiential (early menarche), in 2 cohorts. METHODS We included 540 white women with MS or clinically isolated syndrome (N = 156 with genetic data available) and 1,390 white women without MS but with a first-degree relative with MS (Genes and Environment in Multiple...

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The present study was initiated to derive an indirect method for estimating body fat mass (BFM) and to evaluate the correlation between indirect anthropometric techniques for this estimation and to examine the relation of these parameters and of IQ to age of menarche. A total of 578 adolescent girls of ten junior high schools in five educational districts of Mashhad, participated in a cros...

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ژورنال

عنوان ژورنال: Neurology Genetics

سال: 2016

ISSN: 2376-7839

DOI: 10.1212/nxg.0000000000000088